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Leafar:

Ok, but it is possible using a regular hotkey like the spacebar for example???

Yes, but not the spacebar. Spacebar is used to confirm 3d manipulator tool (translate, rotate, scale).
Use Sticky Key with this code:

On Press:

bpy.context.space_data.show_manipulator = True

On Release:

bpy.context.space_data.show_manipulator = False

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